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Innovate Biopharmaceuticals Announces Acceptance of Three Abstracts for the 2020 Digestive Disease Week (DDW) Conference
Highlighting Larazotide's Effect across the Gut-Vascular Barrier - a Fundamental Disease Mechanism in a Variety of Autoimmune and Inflammatory Diseases
Title: EXPLORING THE MECHANISMS OF LARAZOTIDE IN THE REGULATION OF THE TIGHT JUNCTION BARRIER (Abstract # 3348407)
Poster Session Title: Epithelial Junctions and Barrier Function
Title: CHIRALLY-MODIFIED LARAZOTIDE COMPOUND ANALOG #6 FACILITATES RECOVERY OF ISCHEMIC-INJURED PORCINE JEJUNUM VIA RE-ASSEMBLY OF INTRAEPITHELIAL TIGHT JUNCTIONS (Abstract # 3353776)
Poster Session Title: Molecular Mechanisms of Disease: Genetics, Signaling
Title: IN-VIVO ASSESSMENT OF CELIAC CLINICAL FORMULATION OF LARAZOTIDE IN THE PORCINE GASTROINTESTINAL TRACT USING A NOVEL ULTRAFILTRATION MODEL (Abstract # 3348457)
Poster Session Title: Celiac Disease and Gluten Related Disorders Pathogenesis
Executive Chairman of Innovate, Sandeep Laumas, M.D., stated, "Targeting the restoration of the gut-vascular barrier is an emerging field with exciting data from GI diseases, oncology and neurodegenerative diseases. Further data elucidating the mechanism of action and novel formulations of larazotide such as the development of chirally different larazotide molecules helps us address larazotide's pharmacology and bring the next generation of tight junction regulators for the treatment of autoimmune and inflammatory diseases."
"This exciting new work from our collaboration with Innovate is revealing not only novel mechanisms by which larazotide repairs interepithelial tight junctions in injured, or leaky, intestines, but also how to pharmaceutically ensure optimal stability of the peptide therapeutic within the intestine," remarked
Innovate is a clinical-stage biotechnology company focused on developing novel therapeutics for autoimmune and inflammatory diseases. Innovate's lead drug candidate, larazotide acetate, has a mechanism of action that renormalizes the dysfunctional intestinal barrier by decreasing intestinal permeability and reducing antigen trafficking, such as gliadin fragments in celiac disease, and bacterial toxins and immunogenic antigens in nonalcoholic steatohepatitis (
For more information, please visit www.innovatebiopharma.com.
This press release includes forward-looking statements including, but not limited to, statements related to the development of drug candidates, our operations and business strategy. The forward-looking statements contained in this press release are based on management's current expectations and are subject to substantial risks, uncertainty and changes in circumstances. Actual results may differ materially from those expressed by these expectations due to risks and uncertainties, including, among others, those related to our ability to obtain additional capital on favorable terms to us, or at all, including, without limitation, to fund our current and future preclinical studies and clinical trials; the success, timing and cost of our drug development program and our ongoing or future preclinical studies and clinical trials, including, without limitation, the possibility of unfavorable new clinical and preclinical data and additional analyses of existing data, as well as the risks that prior clinical and preclinical results may not be replicated; the lengthy and unpredictable nature of the drug approval process; and our ability to commercialize our product candidates if approved. These risks and uncertainties include, but may not be limited to, those described in our Annual Report on Form 10-K for the year ended
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